# Synthesis of the Spirotetracyclic Core of the Ginkgolides via a Malonyl Radical Cascade

## TL;DR

Scientists developed a new method to synthesize a complex part of ginkgolides, natural compounds found only in Ginkgo biloba trees.

## Contribution

A novel manganese-III-mediated radical cascade enables efficient synthesis of the ginkgolide core structure.

## Key findings

- The synthesis of rings A, B, D, and E of ginkgolides was achieved in nine steps.
- The method uses six simple starting materials and provides diastereoselective results.

## Abstract

The ginkgolides are
a family of terpene trilactone natural
products
exclusive to the Ginkgo biloba tree. Here, we present
a concise synthesis of their spirotetracyclic core via a manganese­(III)-mediated
oxidative radical cascade. Beginning from six simple starting materials,
this route enables the diastereoselective synthesis of rings A, B,
D and E of the natural product in nine steps, laying the foundations
for their total synthesis.