# Distinct resting state neural activity in chronic pain patients who respond to transcranial electric stimulation for pain relief

## TL;DR

This study found that theta brain wave activity in chronic pain patients may predict whether they will benefit from transcranial electric stimulation for pain relief.

## Contribution

The study identifies theta-band oscillatory activity as a potential biomarker for predicting tES response in chronic pain patients.

## Key findings

- The tES intervention did not significantly alter resting-state power spectral density in theta, alpha, or beta bands.
- Responders to tES had higher theta-band power compared to non-responders, regardless of pre- or post-intervention assessment.

## Abstract

Transcranial electric stimulation (tES) techniques have shown promising results for pain relief in chronic pain. However, little is known about the mechanisms by which these non-invasive neuromodulation techniques produce analgesic effects. Besides, previous studies underscore the need to identify profiles of patients with a better response to tES.

In this randomized clinical trial (ClinicalTrials.gov: NCT05099406), we studied whether tES modulate brain oscillatory activity by recording resting state EEG (eyes open) from 106 chronic pain patients before and after a 15-day home-based intervention with either transcranial direct or alternate current stimulation, or sham stimulation. Power spectral density (PSD) at rest was analyzed in the theta, alpha, and beta frequency bands, in two 2 × 2 designs with the factor time (pre vs. post intervention session) and group, with each active tES condition being compared against the sham stimulation. Additionally, we compared responders vs non-responders to active tES (according to their reported pain relief after the intervention) in the same PSD indices.

The analysis showed that the intervention had no significant effects on PSD in any band, and thus revealed that understanding the physiological mechanisms of the analgesic effects of tES remains a pending matter. However, higher PSD in the theta band was observed for responders compared to non-responders regardless of the assessment session.

This finding suggests that the theta-band oscillatory activity of patients with chronic pain could be a promising prognostic biomarker for the effectiveness of tES and opens a new avenue for individualizing tES interventions.