# Investigation of long-term epigenetic changes in the Nr3c1 gene by neonatal valproate exposure in juvenile rats

**Authors:** Eun Hye Jang, Soon Ae Kim

PMC · DOI: 10.1016/j.gendis.2025.101588 · 2025-03-08

## Full-text entities

- **Genes:** Sox6 (SRY-box transcription factor 6) [NCBI Gene 293165], Nr3c1 (nuclear receptor subfamily 3, group C, member 1) [NCBI Gene 24413] {aka GR, Gcr, Grl}, Mapk1 (mitogen activated protein kinase 1) [NCBI Gene 116590] {aka ERK-2, ERT1, Erk2, p42-MAPK}, ASCL1 (achaete-scute family bHLH transcription factor 1) [NCBI Gene 429] {aka ASH1, HASH1, MASH1, bHLHa46}, Pax6 (paired box 6) [NCBI Gene 25509], Ubr4 (ubiquitin protein ligase E3 component n-recognin 4) [NCBI Gene 313658] {aka Rbaf600}, Shank3 (SH3 and multiple ankyrin repeat domains 3) [NCBI Gene 59312] {aka Prosap2, Spank-2}, Foxp1 (forkhead box P1) [NCBI Gene 297480], FOXO3 (forkhead box O3) [NCBI Gene 2309] {aka AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A}
- **Diseases:** Cancer (MESH:D009369), autism (MESH:D001321), neuroinflammation (MESH:D000090862), ASD (MESH:D000067877), Neurodevelopmental disorders (MESH:D002658)
- **Chemicals:** VPA (MESH:D014635)
- **Species:** Rattus norvegicus (brown rat, species) [taxon 10116], Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12305572/full.md

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Source: https://tomesphere.com/paper/PMC12305572