# Editorial: Recent advances in mitochondrial dysfunction and therapeutics for neurodegeneration and aging

**Authors:** Monokesh K. Sen, Keagan Dunville, Nicole Miles, Michelle Newbery, Neville S. Ng, Lezanne Ooi

PMC · DOI: 10.3389/fncel.2025.1650938 · 2025-07-15

## Full-text entities

- **Genes:** Sirt1 (sirtuin 1) [NCBI Gene 93759] {aka SIR2L1, Sir2, Sir2a, Sir2alpha}, SOD1 (superoxide dismutase 1) [NCBI Gene 6647] {aka ALS, ALS1, HEL-S-44, IPOA, SOD, STAHP}, SUCLA2 (succinate-CoA ligase ADP-forming subunit beta) [NCBI Gene 8803] {aka A-BETA, A-SCS, LINC00444, MTDPS5, SCS-betaA}, Nes (nestin) [NCBI Gene 18008] {aka ESTM46, Ifaprc2, Marc2, RC2}, TLR4 (toll like receptor 4) [NCBI Gene 7099] {aka ARMD10, CD284, TLR-4, TOLL}, HTT (huntingtin) [NCBI Gene 3064] {aka HD, IT15, LOMARS}, Gfap (glial fibrillary acidic protein) [NCBI Gene 14580], OPA1 (OPA1 mitochondrial dynamin like GTPase) [NCBI Gene 4976] {aka BERHS, MGM1, MTDPS14, MTDPS14A, MTDPS14B, NPG}, Tomm20 (translocase of outer mitochondrial membrane 20) [NCBI Gene 67952] {aka 1810060K07Rik, Gm19268, MAS20, MOM19, TOM20, mKIAA0016}, PRKN (parkin RBR E3 ubiquitin protein ligase) [NCBI Gene 5071] {aka AR-JP, LPRS2, PARK2, PDJ}, PINK1 (PTEN induced kinase 1) [NCBI Gene 65018] {aka BRPK, PARK6}, CRMP1 (collapsin response mediator protein 1) [NCBI Gene 1400] {aka CRMP-1, DPYSL1, DRP-1, DRP1, ULIP-3}, Lrrk2 (leucine-rich repeat kinase 2) [NCBI Gene 66725] {aka 4921513O20Rik, 9330188B09Rik, D630001M17Rik, Gm927, cI-46}, Crmp1 (collapsin response mediator protein 1) [NCBI Gene 12933] {aka CRMP-1, DRP-1, Dpysl1, ULIP-3, Ulip3}, SNCA (synuclein alpha) [NCBI Gene 6622] {aka NACP, PARK1, PARK4, PD1}, Coasy (Coenzyme A synthase) [NCBI Gene 71743] {aka 1300003G02Rik, Dpck, Ppat, Ukr1}, STING1 (stimulator of interferon response cGAMP interactor 1) [NCBI Gene 340061] {aka ERIS, MITA, MPYS, NET23, SAVI, STING}, Atp5f1a (ATP synthase F1 subunit alpha) [NCBI Gene 11946] {aka Atp5a1, Atpm, D18Ertd206e, Mom2}, Fis1 (fission, mitochondrial 1) [NCBI Gene 66437] {aka 2010003O14Rik, Ttc11}, Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha) [NCBI Gene 19017] {aka A830037N07Rik, Gm11133, PGC-1, PPARGC-1-alpha, Pgc-1alpha, Pgc1}, Ncoa4 (nuclear receptor coactivator 4) [NCBI Gene 27057] {aka ARA70, NCoA-4, Rfg}, PPARGC1A (PPARG coactivator 1 alpha) [NCBI Gene 10891] {aka LEM6, PGC-1(alpha), PGC-1alpha, PGC-1v, PGC1, PGC1A}, MAPT (microtubule associated protein tau) [NCBI Gene 4137] {aka DDPAC, FTD1, FTDP-17, MAPTL, MSTD, MTBT1}, Nnmt (nicotinamide N-methyltransferase) [NCBI Gene 18113], CYCS (cytochrome c, somatic) [NCBI Gene 54205] {aka CYC, HCS, THC4}
- **Diseases:** CoA-related disorders (MESH:D019973), Pontocerebellar Hypoplasia Type 12 (MESH:C548070), Alzheimer's disease (MESH:D000544), Parkinson's disease (MESH:D010300), hypoxia (MESH:D000860), cognitive and motor decline (MESH:D003072), motor deficits (MESH:D009461), TBI (MESH:D004834), brain injury (MESH:D001930), inflammation (MESH:D007249), mitochondrial failure (MESH:D051437), Mitochondrial (MESH:D028361), weight gain (MESH:D015430), Coasy-linked disorders (MESH:D040181), neurodegeneration (MESH:D019636), neuroinflammation (MESH:D000090862), calcium dysregulation (MESH:D002128), hearing loss (MESH:D034381), Huntington's disease (MESH:D006816), mitochondrial fragmentation (MESH:D012892), motor neuron disease (MESH:D016472), neurodevelopmental disorders (MESH:D002658), proteinopathies (MESH:D057165), brain damage (MESH:D001925), optic atrophy (MESH:D009896), dopaminergic neuron loss (MESH:D009410), necrotic (MESH:D009336), locomotor dysfunction (MESH:D001523)
- **Chemicals:** calcium (MESH:D002118), NAD (MESH:D009243), pyruvate (MESH:D019289), ATP (MESH:D000255), MitoGFP (-), JC-1 (MESH:C068624), kainic acid (MESH:D007608), fat (MESH:D005223), lipid (MESH:D008055), carbohydrates (MESH:D002241), ROS (MESH:D017382), glutamate (MESH:D018698), MNAM (MESH:C024058)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Drosophila melanogaster (fruit fly, species) [taxon 7227], Homo sapiens (human, species) [taxon 9606]
- **Mutations:** G2019S

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12303997/full.md

---
Source: https://tomesphere.com/paper/PMC12303997