# Case Report: Use of Tiao Wei Cheng Qi Decoction to relieve partial intestinal obstruction and enable surgical treatment in primary duodenal adenocarcinoma

**Authors:** Ziyao Li, Jiahang Li, Boyang Li, Yingying Sun, Changcheng Wang

PMC · DOI: 10.3389/fonc.2025.1581949 · 2025-07-15

## TL;DR

A case report shows how a traditional Chinese medicine combined with surgery helped treat a rare intestinal cancer causing blockage.

## Contribution

The paper presents a novel integrative treatment approach combining traditional Chinese medicine and surgery for primary duodenal adenocarcinoma.

## Key findings

- Modified Tiao Wei Cheng Qi Decoction helped relieve intestinal obstruction and improve patient condition.
- Combination therapy enabled successful surgical treatment despite poor initial nutritional status.
- The case provides clinical insights into managing rare duodenal adenocarcinoma with integrative methods.

## Abstract

Primary duodenal adenocarcinoma (PDA) is rare and highly invasive malignancies. The onset of the disease is insidious. Patients are often diagnosed when digestive obstruction occurred, leading to poor nutritional status and reduced tolerance for surgical trauma. Additionally, patients commonly experience fluid depletion and gastric drying, which is recognized as a pattern of gastric dryness and fluid injury. This article presents a successful case treated with the modified Decoction for Regulating the Stomach and Resolving Phlegm Formula combined with partial duodenectomy, summarizes both Chinese and Western medical diagnostic and treatment strategies for this disease, and provides valuable clinical experience in treating it.

## Full-text entities

- **Genes:** ERBB2 (erb-b2 receptor tyrosine kinase 2) [NCBI Gene 2064] {aka CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19}, MSH6 (mutS homolog 6) [NCBI Gene 2956] {aka GTBP, GTMBP, HNPCC5, HSAP, LYNCH5, MMRCS3}, BAX (BCL2 associated X, apoptosis regulator) [NCBI Gene 581] {aka BCL2L4}, S100A1 (S100 calcium binding protein A1) [NCBI Gene 6271] {aka S100, S100-alpha, S100A}, MLH1 (mutL homolog 1) [NCBI Gene 4292] {aka COCA2, FCC2, HNPCC, HNPCC2, LYNCH2, MLH-1}, MSH2 (mutS homolog 2) [NCBI Gene 4436] {aka COCA1, FCC1, HNPCC, HNPCC1, LCFS2, LYNCH1}, PMS2 (PMS1 homolog 2, mismatch repair system component) [NCBI Gene 5395] {aka HNPCC4, LYNCH4, MLH4, MMRCS4, PMS-2, PMSL2}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}
- **Diseases:** malnutrition (MESH:D044342), vascular tumor thrombus (MESH:D013927), nausea (MESH:D009325), abdominal distension (MESH:D000007), vomiting (MESH:D014839), weight loss (MESH:D015431), abdominal pain (MESH:D015746), hypoalbuminemia (MESH:D034141), Fluid Deficiency (MESH:D002559), edema (MESH:D004487), Stomach Dryness (MESH:D013272), gastrointestinal cancers (MESH:D005770), genetic disorders (MESH:D030342), fever (MESH:D005334), reactive hyperplasia (MESH:D019310), constipation (MESH:D003248), fecal (MESH:D005242), nodal (MESH:D013611), digestive obstruction (MESH:D004828), Covid-19 (MESH:D000086382), intestinal obstruction (MESH:D007415), pain (MESH:D010146), COPD (MESH:D029424), respiratory symptoms (MESH:D012818), Yangming syndrome (MESH:D013577), gastroenteritis (MESH:D005759), anastomotic leaks (MESH:D057868), papillary adenocarcinoma (MESH:D000231), gastrointestinal dysfunction (MESH:D005767), Yangming disorder (MESH:D009358), small intestinal malignancies (MESH:C538260), duodenal mass (MESH:D004378), cough (MESH:D003371), cancer (MESH:D009369), PDA (MESH:D000230), inflammation (MESH:D007249), trauma (MESH:D014947), luminal stenosis (MESH:D003251)
- **Chemicals:** anthraquinones (MESH:D000880), propionate (MESH:D011422), water (MESH:D014867), flavonoids (MESH:D005419), short-chain fatty acids (MESH:D005232), Emodin (MESH:D004642), sodium sulfate (MESH:C012036), Glycyrrhizin (MESH:D019695), butyrate (MESH:D002087), acetate (MESH:D000085), glycosides (MESH:D006027), Mang (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12303914/full.md

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Source: https://tomesphere.com/paper/PMC12303914