# Newly Diagnosed HIV in an Octogenarian Woman: A Case Report on Delayed Diagnosis in Vulnerable Populations

**Authors:** HeeKyoung Choi, Myung Hee Chang, Heun Choi, Wooyong Jeong

PMC · DOI: 10.1002/ccr3.70654 · 2025-07-28

## TL;DR

An elderly woman was diagnosed with HIV while being treated for lymphoma, showing the need for better awareness and testing in vulnerable older populations.

## Contribution

Highlights the importance of HIV testing in elderly, socially isolated individuals without traditional risk factors.

## Key findings

- An 85-year-old woman with no known HIV risk factors was diagnosed with HIV during lymphoma staging.
- Antiretroviral therapy led to immunologic improvement and viral suppression in the patient.
- The case emphasizes the need for increased HIV testing in vulnerable elderly populations.

## Abstract

HIV infection in elderly individuals is often under recognized due to stigma, low clinical suspicion, and communication barriers. We present the case of an 85‐year‐old woman from a rural area who was diagnosed with HIV during staging workup for newly diagnosed diffuse large B‐cell lymphoma. Her HIV viral load was 70,650 copies/mL and CD4 count was 83 cells/mm3 at diagnosis. She was illiterate, socially isolated, and had no known risk factors. Antiretroviral therapy was initiated with Biktarvy, resulting in gradual immunologic improvement and viral suppression. This case highlights the need to consider HIV testing in older adults with social vulnerability, even when classical risk factors are absent.

## Linked entities

- **Chemicals:** Biktarvy (PubChem CID 129626368)
- **Diseases:** diffuse large B-cell lymphoma (MONDO:0018905)

## Full-text entities

- **Genes:** CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}
- **Diseases:** immunologic abnormalities (MESH:D007154), lymphoma (MESH:D008223), infectious disease (MESH:D003141), infection (MESH:D007239), malignancies (MESH:D009369), opportunistic infection (MESH:D009894), hepatitis C (MESH:D019698), death (MESH:D003643), diffuse large B-cell lymphoma (MESH:D016403), dementia (MESH:D003704), hepatitis (MESH:D056486), B-cell lymphoma (MESH:D016393), ischemic heart disease (MESH:D017202), hepatitis B (MESH:D006509), cognitive decline (MESH:D003072), HIV (MESH:D015658), frailty (MESH:D000073496), confusion (MESH:D003221), psychiatric (MESH:D001523), gastric ulcer (MESH:D013276), memory disturbances (MESH:D008569)
- **Chemicals:** bictegravir (MESH:C000620396), Biktarvy (MESH:C000654125), trimethoprim/sulfamethoxazole (MESH:D015662), tenofovir alafenamide (MESH:C442442), emtricitabine (-)
- **Species:** Homo sapiens (human, species) [taxon 9606], Human immunodeficiency virus 1 (no rank) [taxon 11676]

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Source: https://tomesphere.com/paper/PMC12303848