Periodontal Health and Total Antioxidant Capacity for Jordanian Smokers at Dental Teaching Clinic
Noor Al Mortadi, Khaled Al Qudah, Sabha Alshatrat, Karem H. Alzoubi, Rania Mahafdeh

TL;DR
This study shows that smoking worsens periodontitis by increasing oxidative stress and damaging liver and kidney function in Jordanian patients.
Contribution
The study is the first to simultaneously assess systemic antioxidant capacity, organ function, and hematological indices in smokers with periodontitis.
Findings
Smokers with periodontitis had higher oxidative stress markers (TBARS) in serum and saliva.
Smokers showed reduced antioxidant enzyme levels (GSH, GPX, SOD, TAOA) and elevated liver enzymes (ALT, AST).
Smoking was linked to higher BUN and creatinine levels, indicating kidney dysfunction and systemic inflammation.
Abstract
Background: Smoking exacerbates oxidative stress and inflammation, both of which contribute to periodontitis. However, few studies have simultaneously assessed/systemic antioxidant capacity, organ function, and hematological indices in smokers with periodontitis. This study aimed to examine antioxidant enzymes, hepatic and renal function, and hematological profiles, offering a comprehensive perspective on smoking-related periodontal damage. Methods: A total of 47 participants were divided into three groups: smokers with periodontitis (n = 18), nonsmokers with periodontitis (n = 17), and healthy nonsmoking controls without periodontitis (n = 12). Salivary and blood samples were collected, and oxidative stress biomarkers, including thiobarbituric acid reactive substances (TBARS) and antioxidant enzymes, such as glutathione (GSH), GSH peroxidase (GPX), superoxide dismutase (SOD), and…
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Taxonomy
TopicsOral microbiology and periodontitis research · Oral Health Pathology and Treatment · Dental Health and Care Utilization
