# Adult-Onset Multisystem Langerhans Cell Histiocytosis With Bone and Hepatic Involvement: A Rare Case With Radiologic-Pathologic Correlation

## TL;DR

A rare case of Langerhans cell histiocytosis involving the bone and liver is presented, highlighting the importance of biopsy for accurate diagnosis.

## Contribution

This case report provides a radiologic-pathologic correlation for a rare presentation of LCH with hepatic involvement.

## Key findings

- A 22-year-old man presented with a cervical spine fracture suspicious for metastasis but was diagnosed with LCH.
- Liver imaging and histopathology confirmed LCH rather than metastatic cancer.
- The case emphasizes the need for biopsy in diagnosing multiorgan LCH.

## Abstract

Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of histiocytic dendritic cells that can mimic metastatic malignancies due to its potential for multiorgan involvement. Histopathologic confirmation is essential for accurate diagnosis. As such, biopsy is imperative, especially in patients who present with hepatic lesions. Adjunctive liver imaging can help confirm the diagnosis, but is rarely performed. Little information is available on imaging features of hepatic involvement in LCH. Here we report a case of a 22-year-old man with a fracture of his cervical spine suspicious for pathological fracture. However, liver imaging and confirmatory histopathology revealed LCH instead of metastatic spread.