# Clinical study of renal damage in patients with Type-1 diabetic nephropathy based on shear wave elastography and hemodynamics

## TL;DR

This study shows that shear wave elastography and hemodynamic measurements can non-invasively assess kidney damage in Type-1 diabetic patients.

## Contribution

The study introduces a non-invasive method using SWE and hemodynamics to evaluate renal damage severity in Type-1 diabetic nephropathy.

## Key findings

- Elasticity indexes in the renal cortex and medulla were significantly higher in diabetic patients compared to healthy controls.
- Hemodynamic parameters like peak systolic and diastolic velocities decreased with higher disease severity.
- Resistive index was significantly lower in advanced stages of diabetic nephropathy.

## Abstract

To evaluate the clinical value of shear wave elastography(SWE) and hemodynamics in renal damage in patients with Type-1 diabetic nephropathy.

This was a retrospective study. One hundred and ten patients with Type-1 diabetic nephropathy in The People’s Hospital of Qingyuan District from January 2021 to January 2024 were selected as the study group, while sixty healthy subjects in the same period were selected as the healthy control group. The elasticity indexes of renal cortex and medulla in two groups were compared, as well as the hemodynamic indexes of different severity of patients.

The parameters such as Young’s modulus E value and shear wave velocity in the renal cortex and medulla in the study group were significantly higher than those in the control group (p=0.00). Young’s modulus (E values) in the renal cortex and medulla in patients with diabetic nephropathy was positively correlated with urinary protein, serum creatinine, and serum uric acid concentration (p=0.00). Peak systolic velocity(PS), peak diastolic velocity(ED), mean velocity(TAMx), and minimum velocity(TAMn) in the arteries of kidney of the control group and early-stage group were significantly higher than those in the mid and late-stage groups (p=0.00), while resistive index(RI) was significantly lower (p=0.00).

SWE and hemodynamic testing may evaluate the severity of renal damage in patients with Type-1 diabetic nephropathy in a non-invasive manner, thereby providing references for dynamic monitoring of disease progression, evaluating the effect of clinical intervention, and adjusting treatment regimens.