# Diagnostic and prognostic relevance of RAF1 gene in acute myeloid leukemia

## TL;DR

The RAF1 gene shows promise as a diagnostic and prognostic marker for acute myeloid leukemia.

## Contribution

The study identifies RAF1 as a potential biomarker for both diagnosing and predicting outcomes in AML.

## Key findings

- RAF1 gene expression is significantly increased in AML patients.
- RAF1 demonstrates strong diagnostic potential for AML through ROC curve analysis.
- Bioinformatics analysis supports RAF1's prognostic value in AML.

## Abstract

•Increased RAF1 gene expression in AML.•Significant diagnostic potential of RAF1 gene for AML.•Strong prognostic potential of RAF1 gene for AML.

Increased RAF1 gene expression in AML.

Significant diagnostic potential of RAF1 gene for AML.

Strong prognostic potential of RAF1 gene for AML.

Acute Myeloid Leukemia (AML) demands precise diagnostic and prognostic tools for accurate detection and personalized-treatment strategies. Using Real-Time PCR, we investigated the RAF1, miR-146 b-3p, and Circ-RPL15 network expression in AML. Because RAF1 is a crucial gene involved in various ways, it is considered a potential biomarker for prognosis and diagnosis. While no significant correlation was found within the network, RAF1 expression showed a marked difference between groups. ROC curve analysis for RAF1 demonstrated promising diagnostic performance, and our bioinformatics investigations supported its strong prognostic potential. Identifying such biomarkers can aid in developing better management based on patients' characteristics.