# Ulcerative Esophagitis Caused by Cytomegalovirus During Infectious Mononucleosis in a Young and Immunocompetent Male Patient‐A Case Report

**Authors:** Duje Apostolski, Dietmar Reitgruber, Carina Primus‐Grabscheit, Zsofia Hetzmann, Johann Auer

PMC · DOI: 10.1002/ccr3.70676 · Clinical Case Reports · 2025-07-28

## TL;DR

A young, healthy man developed esophagitis caused by cytomegalovirus during infectious mononucleosis, highlighting the need for broader awareness and further study.

## Contribution

Reports a rare case of CMV-induced esophagitis in an immunocompetent patient with infectious mononucleosis.

## Key findings

- CMV esophagitis occurred in an immunocompetent patient with infectious mononucleosis.
- Symptoms worsened during active CMV infection despite no prior immunodeficiency.
- Antiviral therapy and immunodeficiency screening may be warranted in similar cases.

## Abstract

Cytomegalovirus esophagitis mostly occurs in immunodeficient and severely acutely ill patients. Moreover, this diagnosis should be considered in otherwise healthy patients that experience reflux esophagitis symptom worsening under active CMV infectious mononucleosis. Antiviral therapy and screening for immunodeficiency may be considered; however, more studies are needed to support this claim.

## Linked entities

- **Diseases:** infectious mononucleosis (MONDO:0005810)

## Full-text entities

- **Diseases:** Cytomegalovirus esophagitis (MESH:D003586), CMV infectious mononucleosis (MESH:D007244), reflux esophagitis (MESH:D005764), immunodeficiency (MESH:D007153), Ulcerative Esophagitis (MESH:D004941)
- **Species:** Homo sapiens (human, species) [taxon 9606], Cytomegalovirus (genus) [taxon 10358]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12301690/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12301690/full.md

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Source: https://tomesphere.com/paper/PMC12301690