Homocysteine, HHcy, H-type hypertension and dizziness: an NHANES analysis

TL;DR

This study finds that high homocysteine levels and H-type hypertension are linked to various types of dizziness, suggesting their importance in diagnosis and treatment.

Contribution

The study provides new evidence on the associations between homocysteine, H-type hypertension, and dizziness using a large population dataset.

Findings

Elevated homocysteine levels and H-type hypertension are significantly associated with various symptomatic dizziness.

HHcy shows the strongest link with fall risk, while H-type hypertension is most associated with any dizziness.

Non-linear relationships exist between homocysteine levels and dizziness symptoms.

Abstract

Homocysteine (Hcy) is associated with various diseases, but its specific relationship with different types of dizziness remains unclear.

This study utilizes NHANES cross-sectional data to investigate the associations between Hcy levels, H-type hypertension, and various symptomatic dizziness, aiming to provide new insights for clinical diagnosis and treatment.

This cross-sectional study analyzed 6,970 participants from NHANES (1999–2004) using weighted logistic regression, trend tests, restricted cubic spline analysis, and subgroup analysis.

Elevated Hcy levels and H-type hypertension showed significant positive associations with various symptomatic dizziness. HHcy showed the strongest association with fall risk (OR = 1.83, 95% CI: 1.24–2.77), while H-type hypertension was most strongly associated with any symptomatic dizziness (OR = 1.75, 95% CI: 1.34–2.28). No significant associations were found with positional dizziness. Trend analysis indicated a significant upward trend in the risk of any symptomatic dizziness, balance problems, and falling problems. RCS analysis demonstrated non-linear relationships between Hcy levels and various symptomatic dizziness, including any symptomatic dizziness, balance problems, and falling problems.

This study revealed that Hcy levels, HHcy, and H-type hypertension were significantly associated with various symptomatic dizziness. Recognizing and controlling HHcy and H-type hypertension are vital for dizziness management and diagnosis.

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