# Editorial: Ironome: a still untapped frontier

**Authors:** Gloria C. Ferreira, Vladimir N. Uversky, Zoubida Karim

PMC · DOI: 10.3389/fmolb.2025.1651154 · 2025-07-14

## Full-text entities

- **Genes:** KCNQ1OT1 (KCNQ1 opposite strand/antisense transcript 1) [NCBI Gene 10984] {aka KCNQ1-AS2, KCNQ10T1, Kncq1, KvDMR1, KvLQT1-AS, LIT1}, Gpx4 (glutathione peroxidase 4) [NCBI Gene 625249] {aka GPx-4, GSHPx-4, PHGPx, mtPHGPx, snGPx}, SLC11A2 (solute carrier family 11 member 2) [NCBI Gene 4891] {aka AHMIO1, DCT1, DMT1, NRAMP2}, HAMP (hepcidin antimicrobial peptide) [NCBI Gene 57817] {aka HEPC, HFE2B, LEAP1, PLTR}, TFRC (transferrin receptor) [NCBI Gene 7037] {aka CD71, IMD46, T9, TFR, TFR1, TR}, ALAS2 (5'-aminolevulinate synthase 2) [NCBI Gene 212] {aka ALAS-E, ALASE, ANH1, ASB, SIDBA1, XLDPP}, CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, SLC11A1 (solute carrier family 11 member 1) [NCBI Gene 6556] {aka LSH, NRAMP, NRAMP1}, FOXP3 (forkhead box P3) [NCBI Gene 50943] {aka AIID, DIETER, IPEX, JM2, PIDX, XPID}
- **Diseases:** iron overload (MESH:D019190), X-linked erythropoietic protoporphyria (OMIM:300752), central nervous system (CNS) disorders (MESH:D002493), intrinsic disorder (MESH:D020919), inflammatory (MESH:D007249), infection (MESH:D007239), phototoxic reactions (MESH:D017484), malaria (MESH:D008288), liver damage (MESH:D056486), painful (MESH:D010146), CL (MESH:D016773), genetic and metabolic disorder (MESH:D030342), neuroinflammatory (MESH:D000090862), neurodegeneration (MESH:D019636), lysosomal storage disorder (MESH:D016464), toxicity (MESH:D064420), neuronal loss (MESH:D009410), MPS III (MESH:D009084), autoimmune (MESH:D001327)
- **Chemicals:** ZnPP (MESH:C017803), fatty acid (MESH:D005227), lipid (MESH:D008055), metal (MESH:D008670), H2O2 (MESH:D006861), Fe2+ (-), calcium (MESH:D002118), Iron (MESH:D007501), heme (MESH:D006418), PPIX (MESH:C028025), glutathione (MESH:D005978)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606], Plasmodium (subgenus) [taxon 418103], Leishmania (subgenus) [taxon 38568], Pseudomonas aeruginosa (species) [taxon 287]

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Source: https://tomesphere.com/paper/PMC12301187