# Spurious Hyperphosphatemia From Alteplase‐Treated Catheter: A Case Report and Literature Review

**Authors:** Ahmad Matarneh, Sundus Sardar, Omar Salameh, Muhammad Abdulbasit, Wardah Iqbal, Monika Koirala, Taryn Millete, Ronald Miller, Nasrollah Ghahramani, Navin Verma

PMC · DOI: 10.1002/ccr3.70665 · 2025-07-27

## TL;DR

This paper reports a case where alteplase-treated dialysis catheters caused falsely high phosphate levels in blood tests.

## Contribution

It highlights the importance of recognizing spurious hyperphosphatemia to avoid misdiagnosis and treatment errors.

## Key findings

- Alteplase use in dialysis catheters can lead to falsely elevated phosphate levels.
- Phosphorus-containing excipients in alteplase are responsible for the spurious readings.
- Accurate phosphate monitoring is crucial for patients on hemodialysis.

## Abstract

Falsely elevated phosphate levels can occur when blood is drawn after alteplase use in dialysis catheters due to phosphorus‐containing excipients. Recognizing spurious hyperphosphatemia is important to prevent misdiagnosis, avoid inappropriate treatment changes, and ensure accurate phosphate monitoring in patients undergoing maintenance hemodialysis.

## Full-text entities

- **Diseases:** Spurious Hyperphosphatemia (MESH:D054559)
- **Chemicals:** phosphorus (MESH:D010758), phosphate (MESH:D010710)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12301157/full.md

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Source: https://tomesphere.com/paper/PMC12301157