Polymer-Based Mass Cytometry Reagents: Synthesis and Biomedical Applications
Yin-Feng Wang, Wenying Wu, Ya-Hui Ge
TL;DR
This paper reviews polymer-based reagents used in mass cytometry, highlighting their design, synthesis, and biomedical applications for single-cell analysis.
Contribution
The paper provides a comprehensive analysis of recent advances in polymer-based reagents for mass cytometry and outlines future research directions.
Findings
Polymer-based reagents offer structural versatility and high metal-loading capacity for mass cytometry.
Three key categories of reagents are analyzed: metal-chelating polymers, polymeric particles, and metal–organic frameworks.
These materials address limitations in sensitivity and multiplexing capacity compared to conventional flow cytometry.
Abstract
Mass cytometry has promoted the development of single-cell analysis by enabling the highly multiplexed detection of cellular markers using metal-tagged antibodies or cells. Polymer-based mass cytometry reagents have played a critical role in this technique due to their structural versatility, high metal-loading capacity, and sensitivity. This review comprehensively examines the advances in polymer-based reagents for mass cytometry, focusing on their design principles, synthetic strategies, and biomedical applications. We systematically analyze three key categories: metal-chelating polymers with macrocyclic/acyclic chelators developed through controlled polymerization techniques, polymeric particles including encoded microspheres and semiconducting polymer dots, and emerging metal–organic frameworks with high metal-loading capacities. The discussion highlights how these engineered…
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Taxonomy
TopicsAdvanced Biosensing Techniques and Applications