# Synthesis and Application of a New Cyclic Phosphoric Acid in Enantioselective Three-Component Mannich Reactions

## TL;DR

Scientists created a new chiral phosphoric acid catalyst that efficiently promotes a specific chemical reaction with high enantioselectivity.

## Contribution

A new cyclic phosphoric acid was synthesized and shown to catalyze enantioselective three-component Mannich reactions effectively.

## Key findings

- The catalyst achieved up to 89% enantiomeric excess in the reactions.
- A three-step synthesis route was developed for the chiral phosphoric acid.
- DFT calculations were used to study the catalytic mechanism.

## Abstract

A novel point-chiral six-membered cyclic phosphoric acid was synthesized starting from an enantiopure precursor via a concise three-step route. Its catalytic performance was evaluated in enantioselective three-component Mannich reactions. Under optimized conditions, the catalyst provided good yields and satisfactory enantiomeric excesses (up to 89%). The basic mechanism of the catalysis was also studied by the DFT method.