Nocardia cyriacigeorgica in a Mallard (Anas platyrhynchos) from Arizona, USA

TL;DR

A mallard in Arizona was found to have a rare Nocardia infection, highlighting the pathogen's potential impact on birds.

Contribution

This case expands the known host range of Nocardia cyriacigeorgica to include wild birds and provides diagnostic insights.

Findings

Nocardia cyriacigeorgica was identified in a mallard through histopathology and bacterial culture.

The infection presented as airsacculitis with granulomas and filamentous bacteria.

The case suggests the need for improved diagnostics to detect nocardiosis in birds.

Abstract

Nocardia spp. are opportunistic pathogens of humans, domestic animals, and wildlife that can cause high levels of morbidity and mortality. Here, we present a unique case of nocardial airsacculitis in a free-ranging mallard (Anas platyrhynchos) from Arizona, USA, and compare it to the hosts, geographic distribution, diagnostic methodology, and infection site of known nocardiosis cases in birds. A gross necropsy, histopathology, and bacterial culture were performed. There were no gross findings associated with the nocardiosis. Histopathology showed multiple granulomas expanding the air sac with intralesional filamentous bacteria that were Grocott’s methenamine silver-positive, Fite–Faraco and Ziehl–Neelsen acid-fast, positive with the Periodic acid–Schiff reaction, and variably Gram-positive. The organism was isolated in culture and identified as Nocardia cyriacigeorgica based on the sequencing of a 463 bp portion of the 16S rRNA gene. While reports of nocardiosis in the class Aves are rare and some are possibly misdiagnosed due to limited diagnostics, cases are reported globally, sometimes resulting in epizootics. More information is needed to understand whether immunosuppression plays a role in disease development in birds. Known to be an emerging pathogen in humans, N. cyriacigeorgica can be considered as a differential diagnosis for pulmonary and potentially cutaneous or disseminated infections in birds.

Figures