# Anti-Obesity Effect of Liposomal Suspension and Extracts of Hibiscus sabdariffa and Zingiber officinale in a Murine Model Fed a Hypercaloric Diet

## TL;DR

This study shows that a liposomal suspension made from Hibiscus and ginger extracts can reduce obesity and related health risks in mice.

## Contribution

The novel use of liposomal suspension enhances the anti-obesity effects of Hibiscus sabdariffa and Zingiber officinale extracts.

## Key findings

- Liposomal suspension reduced body weight and epididymal fat in mice.
- Treatment improved lipid profiles and reduced aspartate aminotransferase activity.
- Liposomal suspension increased locomotor activity and energy expenditure.

## Abstract

Background/Objectives: Obesity is the primary risk factor for the development of chronic degenerative diseases. Multidisciplinary treatments target multiple pathologies associated with obesity. In this study, a potential adjuvant therapy was evaluated by combining extracts from Hibiscus sabdariffa and Zingiber officinale. These extracts were used in both a simple and liposomal suspension, the latter aimed at enhancing the activity of phenolic compounds and determining various metabolic benefits. Methods: In this research, the use of biotechnological approaches for the development of a liposomal suspension formulation with appropriate characteristics of stability, particle size, polydispersity index, concentration, and zeta potential induced an effective reduction in body weight and epididymal fat in a murine obesity model over 8 and 45 days. Results: Treatment with the liposomal suspension reduced variables in the lipid profile, aspartate aminotransferase activity, and energy expenditure, while also promoting an increase in locomotor activity. Conclusions: Therefore, it is suggested that the liposomal suspension represents an alternative for obesity treatment and the reduction of cardiovascular risks.