# Cyber-Physical System Interface for Implantable Esophageal Prosthesis

**Authors:** Ana Magdalena Anghel, Teodora Mîndra

PMC · DOI: 10.3390/s25144469 · 2025-07-18

## TL;DR

This paper introduces a cyber-physical system interface for an implantable esophageal prosthesis, enabling real-time monitoring and analysis of its performance in a simulated environment.

## Contribution

The novel contribution is the integration of a MATLAB-based CPSI with real-time sensor data for modeling and analyzing implantable prosthesis behavior in vivo.

## Key findings

- The CPSI enables accurate simulation of prosthesis positioning and environmental interactions.
- Two applications demonstrate monitoring of prosthesis geometry and tissue response.
- The framework is adaptable for various in vivo implants and systems.

## Abstract

This article presents a Cyber-Physical System Interface (CPSI) for a patented implantable esophageal prosthesis. Designed for in vivo use, the CPSI has been implemented in a MATLAB (version R2021b) simulation environment integrated with real-time data from sensors relevant for monitoring the prosthesis’s physical positioning and environmental interactions, aggregated through an Arduino external system. This setup enables the modeling and analysis of system behaviors in a controlled setting. The paper discusses the sensors, hardware and software components supporting a wide range of applications, and the method chosen for sensor-to-display flow. The case study demonstrates two monitoring system applications: one analyzes the influence of variations in the prosthesis geometry, while the other evaluates the tissue response to the implant. The proposed framework and implementation are highly relevant for a wide range of in vivo implants and related systems.

## Full-text entities

- **Diseases:** CPSI (MESH:D059445), inflammation (MESH:D007249), injury to (MESH:D014947), gastroesophageal reflux (MESH:D005764), Barrett's esophagus (MESH:D001471), eosinophilic esophagitis (MESH:D057765), cancer (MESH:D009369), esophageal disorders (MESH:D004941), tremor (MESH:D014202), colorectal, pancreatic, and hepatobiliary cancer (MESH:D015179), swallowing disorders (MESH:D003680), erosions (MESH:D014077), infections (MESH:D007239), benign esophageal diseases (MESH:D004935), gastrointestinal cancer (MESH:D005770), esophageal cancer (MESH:D004938)
- **Chemicals:** Cu2O (MESH:C000520), PEDOT:PSS (MESH:C533756), DHT.h (MESH:C049564), ZnO (MESH:D015034), DHT11 (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12299741/full.md

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Source: https://tomesphere.com/paper/PMC12299741