# Pharmacology and Toxicology of Opioids—Recent Advances and New Perspectives

**Authors:** Joana Barbosa, Ricardo Jorge Dinis-Oliveira, Juliana Faria

PMC · DOI: 10.3390/ph18071055 · 2025-07-18

## Full-text entities

- **Genes:** ARRB1 (arrestin beta 1) [NCBI Gene 408] {aka ARB1, ARR1}
- **Diseases:** toxicity (MESH:D064420), cardiovascular and autonomic disturbances (MESH:D002318), deaths (MESH:D003643), opioid overdose (MESH:D000083682), hippocampal damage (MESH:D000092223), Sepsis (MESH:D018805), overdose (MESH:D062787), cancer pain (MESH:D000072716), Prolonged (MESH:D008133), septic shock (MESH:D012772), cardiac (MESH:D006331), constipation (MESH:D003248), chronic pain (MESH:D059350), neuropathic (MESH:D009437), neuroinflammation (MESH:D000090862), Cardiopulmonary Dysregulation (MESH:D006323), acute and post-operative pain (MESH:D010149), Cancer (MESH:D009369), neurotoxic (MESH:D020258), behavioral dysfunction (MESH:D001523), addictive behaviors (MESH:D000437), pain (MESH:D010146), alterations (MESH:D004408), inflammation (MESH:D007249), neurodegeneration (MESH:D019636), injury to (MESH:D014947), acute pain (MESH:D059787), opioid addiction (MESH:D009293), hypotension (MESH:D007022), Neurobehavioral Toxicity (MESH:D019954), respiratory depression (MESH:D012131)
- **Chemicals:** SR-14968 (-), ADL5859 (MESH:C532570), serotonin (MESH:D012701), Tramadol (MESH:D014147), dopamine (MESH:D004298), Morphine (MESH:D009020), Cebranopadol (MESH:C000589289), naloxone (MESH:D009270), oliceridine (MESH:C586842), Tapentadol (MESH:D000077432), Dezocine (MESH:C010827), norepinephrine (MESH:D009638), methocinnamox (MESH:C412891), Fentanyl (MESH:D005283)
- **Species:** Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116], Mus musculus (house mouse, species) [taxon 10090]
- **Cell lines:** SKH1 — Homo sapiens (Human), Chronic myelogenous leukemia, BCR-ABL1 positive, Cancer cell line (CVCL_C124)

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Source: https://tomesphere.com/paper/PMC12299398