Optimizing Burn Wound Healing: The Critical Role of pH and Rheological Behavior in Plant-Derived Topical Formulations
Oana-Janina Roșca, Georgeta-Hermina Coneac, Roxana Racoviceanu, Alexandru Nistor, Ioana-Viorica Olariu, Ana-Maria Cotan, Roxana Negrea-Ghiulai, Cristina Adriana Dehelean, Lavinia Lia Vlaia, Codruța Marinela Șoica
TL;DR
This study shows that plant-based oleogels with specific pH and texture properties can improve burn wound healing in rats.
Contribution
The study introduces optimized plant-derived oleogels with pH and rheological properties that enhance burn wound healing.
Findings
Oleogels outperformed hydrogels in wound healing, reducing size and inflammation.
Boswellia serrata and Ocimum basilicum in oleogels showed significant healing benefits by day 21.
Low pH, high viscosity, and thixotropic behavior correlated with better healing outcomes.
Abstract
Background: In burn injuries, wound healing effectiveness is complex and influenced significantly by the local biochemical environment and the physicochemical properties of topical preparations. pH lesions modulation can influence protection barrier integrity, inflammatory responses, and microbial colonization. Their antioxidant, antimicrobial, and anti-inflammatory properties, of the topical formulations enriched with plant extracts have demonstrated promising results. Objective: The aim of the study was to develop and characterize topical oleogel and hydrogel formulations containing ethanolic and hydroalcoholic extracts of medicinal plants (Boswellia serrata, Ocimum basilicum, Sambucus nigra, and Galium verum), and to evaluate the impact of their physicochemical properties, rheological behavior, in contrast with the wound pH modulation, and healing efficacy in an experimental burn…
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Taxonomy
TopicsPharmacological Effects of Medicinal Plants · Wound Healing and Treatments · Essential Oils and Antimicrobial Activity