# Evaluating the Linkage Between Resistin and Viral Seropositivity in Psoriasis: Evidence from a Tertiary Centre

## TL;DR

This study investigates how viral infections might be linked to psoriasis and immune resistance in patients, aiming to improve diagnosis and treatment.

## Contribution

The study provides new evidence on the relationship between viral seropositivity and psoriasis, highlighting the role of immune resistance.

## Key findings

- Notable viral infection rates were found among psoriasis patients, including HSV (8.9%), HCV (4.4%), and HIV (4.4%).
- The study emphasizes the importance of viral testing in psoriasis patients to better understand disease mechanisms.
- Findings suggest a complex interplay between immune factors and viral infections in psoriasis etiology.

## Abstract

Psoriasis, a chronic immune-mediated inflammatory skin disorder, presents complex pathogenetic mechanisms potentially influenced by viral infections. This comprehensive study explored the possible interplay of resistance and viral infections among psoriasis patients using serological screening techniques. The investigation involved 90 patients aged 23–45 years, systematically examining viral seropositivity for HSV (herpes simplex virus), HZ (herpes zoster), HBV (hepatitis B virus), HIV (human immunodeficiency virus), and HCV (hepatitis C virus) through ELISA testing. The findings revealed notable active or recent viral infection rates: 8.9% HSV positivity, 2.2% HZ antibody detection, 4.4% HCV positivity, and 4.4% HIV positivity. The research can contribute to current knowledge gaps, broaden the knowledge regarding the relationship between psoriasis and viral infection, and assess resistance, as it can mediate the interaction. The results can lead to improved diagnosis, treatment, and patient care options. This study emphasizes the importance of thorough viral testing for psoriasis patients, as well as focused therapeutic regimens that take into account viral co-infections. It elucidates the complex networks of biological relationships between immune factors, contributes information that is critical to our understanding of the multifactorial etiology of psoriasis, and concludes with a strong argument for investigating the mechanisms of viral involvement in this chronic-relapsing inflammatory disease.