Toxicological Risk Assessment of Coffee Oil (Coffee Seed Oil and Spent Coffee Grounds Oil) as a Novel Food with Focus on Cafestol
Bernadette Maier, Heike Franke, Steffen Schwarz, Dirk W. Lachenmeier
TL;DR
This paper reviews the safety of coffee oil as a novel food, focusing on its diterpene compounds and suggesting moderate consumption is likely safe for healthy adults.
Contribution
The paper provides initial estimations of LOAEL, NOAEL, and ADI for coffee oil diterpenes, offering a risk assessment framework for novel food approval.
Findings
Moderate coffee oil consumption appears safe as it does not significantly affect blood lipid homeostasis.
An estimated safe daily intake of coffee oil is 225 mg assuming 0.4% diterpene content.
Low coffee oil consumption may be acceptable but requires refined risk assessment for novel food approval.
Abstract
Coffee oil derived from spent coffee grounds of Coffea arabica is considered a novel food in the European Union (EU), requiring pre-market approval supported by comprehensive toxicological data. The effects of coffee oil on human health, particularly on blood parameters and liver enzymes, have been investigated in several studies. This review article summarizes the available toxicological literature on coffee oil, including its bioactive diterpenes cafestol and kahweol, which are known for their potential health effects. Considering the different modes of action of these two diterpenes, moderate consumption of coffee oil may be considered safe for healthy adults. Based on the changes in serum values in humans, this review provides initial estimations of LOAEL, NOAEL, and ADI for these diterpenes. The findings suggest that an intake of 225 mg of coffee oil per day might be considered…
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Taxonomy
TopicsCoffee research and impacts · Tea Polyphenols and Effects · Ginkgo biloba and Cashew Applications