# Selective Toxicity of Iron, Manganese Oxide Nanostructure and Laser Wave on Colorectal and Breast Cancer Cell

## TL;DR

This study explores how combining manganese oxide and iron oxide nanoparticles with infrared laser therapy can effectively kill breast and colorectal cancer cells.

## Contribution

The study introduces a novel combination of MnO and Fe2O3 nanoparticles with IR laser therapy for enhanced cancer cell toxicity.

## Key findings

- MnO and Fe2O3 nanoparticles showed inherent toxicity to cancer cells.
- Combining nanoparticles with IR laser radiation significantly increased cytotoxic effects on Skbr3 and HT29 cells.
- The treatment approach demonstrated potential for reducing cancer cell populations effectively.

## Abstract

Cancer is a deadly and multifaceted disease that poses a significant challenge to treatment due to its heterogeneity and ability to adapt and evolve. Despite advancements in research and medicine, the development of effective treatment options remains a major obstacle in the battle against cancer. Manganese oxide (MnO) and iron (III) oxide (Fe2O3) nanoparticles (NPs) are increasingly used for numerous new applications in modern industrial sectors. However, the toxic and treatment impact of MnO and Fe2O3 NPs has not been clearly elucidated on human cell lines at the cellular and molecular levels.

This study aimed to assess the potential cytotoxic effect of combining infrared (IR) laser therapy with MnO and Fe2O3 nanoparticles on breast and colorectal cancer cells for cancer treatment.

We treated the cancer cells with MnO and Fe2O3 NPs and then exposed them to IR radiation for 6, 12, 24, 48, and 72 hours to investigate the effectiveness of this cancer treatment approach. To evaluate cytotoxicity, we conducted assessments on Skbr3 and HT29 cancer cells, both individually and in combination, using various methods.

The findings indicate that despite the inherent toxicity of NPs and IR laser radiation on cancer cells, the utilization of MnO and Fe2O3 NPs in conjunction with IR laser radiation treatment had the highest cytotoxic impact on cancer cells.

These findings suggest that using MnO and Fe2O3 NPs in combination with IR laser therapy has great potential as an effective method for reducing the population of cancer cells.

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