The proton therapy research beamline at the Christie NHS foundation trust
Nicholas T Henthorn, John-William Warmenhoven, Samuel P Ingram, Samuel P Manger, Michael J Merchant, Hywel Owen, Ranald I Mackay, Karen J Kirkby, Michael J Taylor
TL;DR
This paper describes a new proton therapy research facility in the UK that enables detailed biological and dosimetric studies to improve cancer treatment.
Contribution
The paper introduces a unique UK-based proton therapy research beamline with high-throughput irradiation workflows and accurate dosimetry for radiobiological studies.
Findings
The Manchester proton therapy research facility provides a clinically relevant platform for in vitro and in vivo experiments.
A Monte Carlo beam model was developed to predict and validate complex measurements with high accuracy.
High-throughput irradiation workflows and environmental control reduce experimental uncertainties in radiobiological research.
Abstract
Proton therapy is a relatively new modality for cancer treatment and has several open research questions, particularly in the biological realm. Due to large infrastructure costs the modality is reserved for specialist treatment, limiting the patient outcome dataset. This requires supplementation with fundamental research through in vitro and in vivo systems. Similarly, the safety and potential benefits of new treatments, such as FLASH, should be demonstrated in lab environments prior to clinical translation. Greater access to clinically relevant research platforms is required. This work presents the capabilities of the Manchester proton therapy research facility for experimentalists’ assessment to meet their research goals. Details of the research beamline geometry are presented, along with workflows for in vitro sample irradiation within an automated sample handling environmental…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsRadiation Therapy and Dosimetry · Advanced Radiotherapy Techniques · Radiation Effects and Dosimetry