# Endovascular Treatment of a Symptomatic Vertebral Artery Aneurysm in a Puerperal Patient with Neurofibromatosis Type 1—A Case Report and Review of the Literature

**Authors:** Nikola Mirkovic, Marko Prokic, Nikola Prodanovic, Tamara Nikolic Turnic, Nikola Andric, Tijana Prodanovic, Neda Arsenijevic, Ivan Simic, Dragan Knezevic, Aleksandar Matic

PMC · DOI: 10.3390/diseases13070226 · 2025-07-18

## TL;DR

A 33-year-old woman with neurofibromatosis type 1 had a successful endovascular treatment for a vertebral artery aneurysm during the puerperium.

## Contribution

First reported case of a vertebral artery aneurysm treated with a flow diverter stent graft in a puerperal patient with neurofibromatosis type 1.

## Key findings

- Endovascular treatment with a flow diverter stent graft was successful in managing the aneurysm.
- Early diagnosis and timely treatment are crucial to prevent fatal outcomes in such cases.
- The patient had a prior successful treatment of a thyrocervical trunk aneurysm with endovascular coiling.

## Abstract

Introduction: Primary extracranial vertebral artery aneurysms are sporadic in the general population. They are uncommon in individuals with neurofibromatosis type 1. During pregnancy or in the puerperium, the risk of aneurysm rupture in individuals with neurofibromatosis type 1 and extracranial aneurysms is elevated. Rupture of a vertebral artery aneurysm is an emergency condition and can be fatal. Case presentation: We present the case of a 33-year-old woman in the puerperium with neurofibromatosis type 1 who had a vertebral symptomatic artery aneurysm. During a previous hospitalization, two months before the treatment of the vertebral aneurysm, a same-sided aneurysm of the thyrocervical trunk was successfully treated with endovascular coiling because of aneurysm rupture. In this case report, the vertebral artery aneurysm was successfully managed using a flow diverter stent graft. Conclusions: This is the first reported case of a successfully treated symptomatic vertebral artery aneurysm with a flow diverter stent graft in a patient with neurofibromatosis type 1 during the early puerperium. Endovascular treatment with a stent graft is a minimally invasive, safe, and effective treatment for patients with vertebral artery aneurysms. Early diagnosis of non-ruptured vertebral artery aneurysms is a crucial as well as appropriate treatment, which should be undertaken in a timely manner to prevent serious complications or a fatal outcome.

## Linked entities

- **Diseases:** neurofibromatosis type 1 (MONDO:0018975)

## Full-text entities

- **Genes:** NF1 (neurofibromin 1) [NCBI Gene 4763] {aka NFNS, VRNF, WSS}
- **Diseases:** Primary extracranial vertebral artery aneurysms (MESH:D020217), aneurysm (MESH:D000783), artery aneurysm (MESH:D002532), aneurysm rupture (MESH:D017542)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12295916/full.md

---
Source: https://tomesphere.com/paper/PMC12295916