# Gene Therapies in Dermatological Diseases: A Breakthrough in Treatment

## TL;DR

Gene therapy is being explored as a promising treatment for various skin diseases, offering targeted and potentially curative solutions.

## Contribution

The paper reviews recent advancements in gene therapy for dermatological conditions, highlighting new therapeutic strategies and their potential impact.

## Key findings

- Gene therapy is being explored for conditions like epidermolysis bullosa, ichthyosis, psoriasis, chronic wounds, and melanoma.
- Therapeutic strategies include viral vectors, gene editing, RNA-based treatments, and cell-based approaches.
- These methods aim to correct genetic defects, modulate immune responses, and promote tissue repair.

## Abstract

Gene therapy involves introducing genetic material into cells to treat or prevent disease and offers highly targeted and potentially curative approaches for both inherited and acquired conditions. The skin is an especially suitable organ for gene therapy due to its accessibility, ease of sampling, rapid cell turnover, and the possibility for localized treatment with minimal systemic exposure. Gene therapy is being actively explored across a range of dermatological conditions, including recessive dystrophic epidermolysis bullosa, ichthyosis, psoriasis, chronic wounds, and melanoma, with therapeutic strategies encompassing viral vectors, non-viral delivery systems, gene editing technologies, RNA-based treatments, and cell-based approaches. These diverse methods aim to correct genetic defects, modulate immune responses, promote tissue repair, or selectively target malignant cells. This review examines the advancements and potential of gene therapies in addressing complex skin diseases, providing hope for improved patient outcomes and long-term care.