# Recent Evidence for Orthobiologics Combined with Hydrogels for Joint Tissue Regeneration: Focus on Osteoarthritis

## TL;DR

This paper reviews how combining orthobiologics with hydrogels can help regenerate joint tissue in osteoarthritis patients.

## Contribution

The paper highlights recent preclinical and clinical evidence for using orthobiologics with hydrogels in osteoarthritis treatment.

## Key findings

- Orthobiologics combined with hydrogels show promise for treating degenerative joint lesions.
- Tailored therapies based on joint type and disease severity are being explored.
- Natural and synthetic hydrogels are being used in various regenerative approaches.

## Abstract

Osteoarthritis is a significant global problem, causing pain and limitations, and contributing to socioeconomic expenses. The etiopathogenesis of this disease encloses genetic, biological, and mechanical aspects. Regenerative medicine, utilizing tissue engineering, has opened the way to new therapeutic approaches employing various orthobiologics. Combined with hydrogels, these compounds may represent a notable option for treating degenerative and inflammatory lesions in OA. The review reports on the main orthobiologics used in preclinical and clinical studies, as well as their association with various types of natural and synthetic hydrogels. Research may increasingly focus on tailored therapies adjusted to suit the joint involved and the severity of the pathology encountered in each patient.