# Generative AI for Bayesian Computation

**Authors:** Nick Polson, Vadim Sokolov

PMC · DOI: 10.3390/e27070683 · 2025-06-26

## TL;DR

This paper introduces a new Bayesian inference method using generative AI that works for both parametric and non-parametric models, offering advantages over traditional techniques.

## Contribution

The novel contribution is a Quantile Neural Network approach for Bayesian computation that is density-free and uses summary statistics for feature selection.

## Key findings

- The method is demonstrated on a normal–normal model and applied to real-world problems like traffic speed and satellite drag.
- The approach outperforms state-of-the-art methods in certain scenarios.
- The paper identifies future research directions for expanding the method's applicability.

## Abstract

Generative Bayesian Computation (GBC) provides a simulation-based approach to Bayesian inference. A Quantile Neural Network (QNN) is trained to map samples from a base distribution to the posterior distribution. Our method applies equally to parametric and likelihood-free models. By generating a large training dataset of parameter–output pairs inference is recast as a supervised learning problem of non-parametric regression. Generative quantile methods have a number of advantages over traditional approaches such as approximate Bayesian computation (ABC) or GANs. Primarily, quantile architectures are density-free and exploit feature selection using dimensionality reducing summary statistics. To illustrate our methodology, we analyze the classic normal–normal learning model and apply it to two real data problems, modeling traffic speed and building a surrogate model for a satellite drag dataset. We compare our methodology to state-of-the-art approaches. Finally, we conclude with directions for future research.

## Full-text entities

- **Genes:** ABCB6 (ATP binding cassette subfamily B member 6 (LAN blood group)) [NCBI Gene 10058] {aka ABC, LAN, MTABC3, PRP, umat}
- **Diseases:** injury to (MESH:D014947)
- **Chemicals:** S (MESH:D013455)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12294086/full.md

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Source: https://tomesphere.com/paper/PMC12294086