A Microsphere-Based Sensor for Point-of-Care and Non-Invasive Acetone Detection
Oscar Osorio Perez, Ngan Anh Nguyen, Landon Denham, Asher Hendricks, Rodrigo E. Dominguez, Eun Ju Jeong, Marcio S. Carvalho, Mateus Lima, Jarrett Eshima, Nanxi Yu, Barbara Smith, Shaopeng Wang, Doina Kulick, Erica Forzani
TL;DR
This paper introduces a new sensor for detecting acetone in body fluids, which could help monitor metabolic health and diseases non-invasively.
Contribution
A novel microsphere-based colorimetric sensor for selective and stable acetone detection is developed and validated.
Findings
The sensor shows high selectivity for acetone with minimal CO2 interference.
The sensor's performance correlates well with GC-MS, with a strong linear fit and high adjusted R-squared value.
Abstract
Ketones, which are key biomarkers of fat oxidation, are relevant for metabolic health maintenance and disease development, making continuous monitoring essential. In this study, we introduce a novel colorimetric sensor designed for potential continuous acetone detection in biological fluids. The sensor features a polydimethylsiloxane (PDMS) shell that encapsulates a sensitive and specific liquid-core acetone-sensing probe. The microsphere sensors were characterized by evaluating their size, PDMS shell thickness, colorimetric response, and sensitivity under realistic conditions, including 100% relative humidity (RH) and CO2 interference. The microsphere size and sensor sensitivity can be controlled by modifying the fabrication parameters. Critically, the sensor showed high selectivity for acetone detection, with negligible interference from CO2 concentrations up to 4%. In addition, the…
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Taxonomy
TopicsMicrofluidic and Capillary Electrophoresis Applications · Advanced Chemical Sensor Technologies · Advanced Sensor and Energy Harvesting Materials