Continuous Renal Replacement Therapy in Critically-Ill Term and Preterm Newborns: A Single-Center Study in Belgrade

TL;DR

This study examines factors affecting outcomes in critically ill newborns undergoing kidney therapy in a neonatal intensive care unit.

Contribution

The study identifies CRRT duration, anuria, and post-treatment potassium levels as predictors of poor outcomes in neonates.

Findings

CRRT duration, anuria, and elevated potassium levels after treatment are significant predictors of poor outcomes.

Timely initiation and efficient management of CRRT are crucial for improving survival rates in neonates.

Demographic and PRISM III score factors did not significantly correlate with treatment outcomes.

Abstract

Background/Objectives: Continuous renal replacement therapy (CRRT) is an important treatment method that is becoming a commonly-used procedure in neonatal intensive care units (NICUs), especially in critically-ill neonates. Methods: We conducted a retrospective study aimed to evaluate factors influencing the outcomes of CRRT in neonates and preterm infants. The study analyzed data from 41 newborns treated with CRRT at our NICU over a ten-year period. Demographic, clinical, and laboratory parameters were assessed, including gestational age, birth weight, PRISM III score, and laboratory markers like urea, creatinine, and potassium levels, as well as characteristics of CRRT. Results: Our research found that the duration of CRRT, the presence of anuria, and higher potassium levels after initiation of CRRT were significant predictors of a poor outcome. Despite the lack of significant correlation between demographic characteristics, PRISM III score and the outcome, our findings highlight the importance of timely CRRT initiation and efficient management to improve survival. Conclusions: Our study identified several significant prognostic indicators in neonates undergoing renal replacement therapy. While these findings provide valuable insights, further research is needed to establish clear theoretical guidelines and improve clinical decision-making.

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