The Chronological Trigger: The Orchestra Between Homeobox Genes and the Circadian Clock During Development

TL;DR

This paper explores how homeobox genes and the circadian clock interact during development, highlighting their roles in regulating cellular differentiation and embryonic structure formation.

Contribution

The paper provides a critical review and new perspectives on the crosstalk between homeobox genes and circadian regulation in development.

Findings

Homeobox genes and circadian rhythms are interconnected in regulating embryonic development.

The interplay influences cellular differentiation and tissue formation.

New insights into the regulatory mechanisms of development are presented.

Abstract

As master regulators of embryonic development, regulating homeobox genes is fundamental for developmental biology. Despite the growth of multiple topics regarding fine‐tuning homeobox gene expression, the discussion on how the circadian rhythm affects their control and vice‐versa still needs to be improved. Due to the intrinsic importance of the circadian clock and its impact on several molecular mechanisms, including development and pregnancy, the interplay between this mechanism and homeobox genes becomes a meaningful discussion. This work aims to review and critically discuss the crosstalk between homeobox genes and circadian regulation in multiple organisms, focusing on differentiation and developmental mechanisms. A considerable focus is given to new perspectives on the topic.

Homeobox genes associated with the circadian rhythm and the development of specific tissues, playing crucial roles in regulating cellular differentiation and the formation of structures during embryonic development.

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