# Visible Light Optical Coherence Tomography: Technology and Biomedical Applications **Authors:** Songzhi Wu, Shuo Wang, Baihan Li, Zhao Wang PMC · DOI: 10.3390/bioengineering12070770 · 2025-07-17 ## TL;DR Visible light OCT is a new imaging technique that uses visible light to provide detailed images and analysis of biological tissues. ## Contribution This paper reviews the latest developments and applications of visible light OCT, highlighting its potential and challenges. ## Key findings - Visible light OCT offers high-resolution and high-contrast imaging of biological tissues. - The review discusses the current technological advancements and biomedical applications of vis-OCT. - Limitations and future directions for vis-OCT are outlined to guide further research. ## Abstract Compared to widely used near-infrared OCT (NIR-OCT) systems, visible light OCT (vis-OCT) is an emerging imaging modality that leverages visible light to achieve high-resolution, high-contrast imaging and enables detailed spectroscopic analysis of biological tissues. In this review, we provide an overview of the state-of-the-art technology development and biomedical applications of vis-OCT. We also discuss limitations and future perspectives for advancing vis-OCT. ## Full-text entities - **Genes:** Bax (BCL2-associated X protein) [NCBI Gene 12028], PLXNA2 (plexin A2) [NCBI Gene 5362] {aka OCT, PLXN2}, THBS1 (thrombospondin 1) [NCBI Gene 7057] {aka THBS, THBS-1, TSP, TSP-1, TSP1}, Rho (rhodopsin) [NCBI Gene 212541] {aka Noerg1, Opn2, Ops, RP4} - **Diseases:** vascular abnormalities (MESH:D014652), cancer (MESH:D009369), Alzheimer's disease (MESH:D000544), RIN (MESH:D014012), GS (MESH:D005736), glaucomatous eyes (MESH:D005134), cardiac arrest (MESH:D006323), age-related macular degeneration (MESH:D008268), optic (MESH:D009901), neurodegenerative (MESH:D019636), ONC injury (MESH:D014947), retinal pigmented epithelium (MESH:C536309), dendritic degeneration (MESH:D007635), ischemia (MESH:D007511), metabolic dysfunction (MESH:D008659), hypoxia (MESH:D000860), hypoxic (MESH:D002534), RP (MESH:D012174), retinopathy of prematurity (MESH:D012178), retinopathy (MESH:D058437), stroke (MESH:D020521), retinal ganglion (MESH:D012173), Diabetic retinopathy (MESH:D003930), DR (MESH:D004370), retinal degeneration (MESH:D012162), vascular loss (MESH:D057772), toxicity (MESH:D064420), microvascular damage (MESH:D017566), retinal vein occlusion (MESH:D012170), eye diseases (MESH:D005128), cell degeneration (MESH:D002292), TD (MESH:D004409), neuronal damage (MESH:D009410), sickle cell retinopathy (MESH:D000755), amyloid (MESH:C000718787), type-1 diabetic (MESH:D003922), RGC damage (MESH:D012164), involuntary eye movements (MESH:D020820), Glaucoma (MESH:D005901) - **Chemicals:** Oxygen (MESH:D010100), retinal (MESH:D012172), NMDA (MESH:D016202), water (MESH:D014867), latex (MESH:D007840), Ti (MESH:D014025), MNU (MESH:D008770), lipofuscin (MESH:D008062), H&E (MESH:D006371), DCP (-), pilocarpine (MESH:D010862), hematoxylin (MESH:D006416), hydroxychloroquine (MESH:D006886), lithium niobate (MESH:C091692), eosin (MESH:D004801), TD (MESH:C076628) - **Species:** Mus musculus (house mouse, species) [taxon 10090], Rattus norvegicus (brown rat, species) [taxon 10116], Homo sapiens (human, species) [taxon 9606], Rodentia (rodent, order) [taxon 9989], Macaca mulatta (rhesus macaque, species) [taxon 9544], Gallus gallus (bantam, species) [taxon 9031] ## Figures 9 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12292648/full.md --- Source: https://tomesphere.com/paper/PMC12292648