Construction of a Structurally Unbiased Brain Template with High Image Quality from MRI Scans of Saudi Adult Females
Noura Althobaiti, Kawthar Moria, Lamiaa Elrefaei, Jamaan Alghamdi, Haythum Tayeb
TL;DR
This paper creates the first brain template for Saudi adult females using MRI scans, improving accuracy for future brain studies in this population.
Contribution
The first structural brain template for Saudi adult females using MRI scans and a novel method to reduce anatomical bias.
Findings
The template shows enhanced sharpness and tissue contrast compared to existing templates.
The method reduces anatomical bias and sensitivity to outliers in MRI data.
Computational optimizations improved processing efficiency for template construction.
Abstract
In brain mapping, structural templates derived from population-specific MRI scans are essential for normalizing individual brains into a common space. This normalization facilitates accurate group comparisons and statistical analyses. Although templates have been developed for various populations, none currently exist for the Saudi population. To our knowledge, this work introduces the first structural brain template constructed and evaluated from a homogeneous subset of T1-weighted MRI scans of 11 healthy Saudi female subjects aged 25 to 30. Our approach combines the symmetric model construction (SMC) method with a covariance-based weighting scheme to mitigate bias caused by over-represented anatomical features. To enhance the quality of the template, we employ a patch-based mean-shift intensity estimation method that improves image sharpness, contrast, and robustness to outliers.…
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Taxonomy
TopicsFunctional Brain Connectivity Studies · Medical Image Segmentation Techniques · Advanced MRI Techniques and Applications