Regeneration of Insulin-Producing β Cells, Reduction in Inflammation and Oxidation Stress, and Improvement in Lipid Profile in a Type 1 Diabetes Rat Model by Intraperitoneal Injection of the Growth Factors-Rich Catfish Skin-Derived Fraction-B: An Introductory Report
Jassim M. Al-Hassan, Waleed M. Renno, Sosamma Oommen, Divya Nair, Bincy Maniyalil Paul, Bincy Mathew, Jijin Kumar, Afna Ummerkutty, Cecil Pace-Asciak
TL;DR
A catfish skin-derived treatment helped regenerate insulin-producing cells in diabetic rats, reducing inflammation and improving health without side effects.
Contribution
This study introduces a novel catfish skin-derived fraction that regenerates β-cells in a T1D rat model without immunosuppressants.
Findings
FB treatment reduced blood glucose and increased insulin and C-peptide levels in diabetic rats.
Histopathological analysis confirmed regeneration of functional β-cells in pancreatic islets.
FB improved lipid profiles and reduced inflammation and oxidative stress without toxicity.
Abstract
Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells. The regeneration of durable insulin-producing β-cells remains a critical challenge. This study investigated the regenerative potential of Fraction-B (FB), a catfish skin-derived preparation rich in growth factors, in a T1D rat model to regenerate active β-cells. Sprague Dawley rats with T1D caused by streptozotocin injection received daily intraperitoneal injections of FB for 8 weeks. FB treatment significantly reduced blood glucose to a level close to that of normal control animals, increased serum insulin and C-peptide, and restored pancreatic insulin content. Histopathological and immunohistochemical analyses confirmed the regeneration of insulin-producing β-cells in pancreatic islets. FB treatment also improved diabetes-related health issues through a reduction in inflammation and oxidative…
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Taxonomy
TopicsPancreatic function and diabetes · Apelin-related biomedical research · Diet, Metabolism, and Disease