# Grain-Free Diets for Dogs and Cats: An Updated Review Focusing on Nutritional Effects and Health Considerations

**Authors:** Jing Zhang, Yun Ji, Ying Yang, Zhenlong Wu

PMC · DOI: 10.3390/ani15142020 · Animals : an Open Access Journal from MDPI · 2025-07-09

## TL;DR

This review examines the pros and cons of grain-free diets for dogs and cats, focusing on their nutritional impact and health effects.

## Contribution

The study provides an updated analysis of grain-free pet food's nutritional variability and health implications, including risks like DCM in dogs.

## Key findings

- Grain-free diets may improve blood sugar control and palatability but are linked to risks like dilated cardiomyopathy in dogs.
- Grain-free diets do not necessarily reduce allergy risks and have higher protein and fat content compared to other diets.
- Nutritional adequacy and balance are emphasized as essential for pet health, regardless of grain inclusion.

## Abstract

Currently, there is a significant amount of controversy surrounding the advantages and disadvantages of feeding pets grain-free foods. This review provides an analysis of the nutritional composition of currently available grain-free pet foods on the market and evaluates their influence on pet health and welfare. Drawing upon existing scientific evidence, this review explores the multifaceted implications of grain-free diets on various aspects of companion animals, including gastrointestinal health, cardiovascular health, allergy, glycemic regulation, mycotoxin safety, and palatability for pets. With a focus on both canine and feline nutrition, this review aims to better assist pet caregivers in raising their pets in a scientific, economic, and efficient manner.

In recent years, grain-free pet food has gained increasing attention due to its widespread promotion as a natural and hypoallergenic diet. This trend has prompted us to conduct an in-depth critical assessment of the nutritional implications of such diets. This review systematically analyzed the nutritional components of commercially available grain-free pet food, revealing significant variability in the nutritional composition of commercial pet diets. Moreover, grain-free formulations typically exhibit higher protein and fat levels. On the other hand, this review further explores the multifaceted health impacts of these diets on pets, including digestive function, cardiovascular health, allergic reactions, blood sugar regulation, mycotoxin safety, and palatability. This review points out that grain-free diets may offer potential benefits, such as improved blood sugar control, reduced mycotoxin exposure, and enhanced palatability; however, they also pose clear risks, particularly the potential association with dilated cardiomyopathy (DCM) in dogs. Additionally, the presence or absence of grains in the diet does not mitigate the risk of allergies. A grain-free diet is only intended to help specific individuals (such as those who are sensitive to grains/gluten) avoid allergens. Ultimately, the review emphasizes that nutritional adequacy, balance, and meeting individualized needs are the cornerstones of pet health, aiming to provide valuable insights for pet caregivers, veterinarians, and researchers.

## Linked entities

- **Diseases:** dilated cardiomyopathy (MONDO:0005021)

## Full-text entities

- **Diseases:** allergic (MESH:D004342), DCM (MESH:D002311)
- **Chemicals:** blood sugar (MESH:D001786)
- **Species:** Felis catus (cat, species) [taxon 9685], Canis lupus familiaris (dog, subspecies) [taxon 9615]

## Full text

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## Figures

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## References

180 references — full list in the complete paper: https://tomesphere.com/paper/PMC12291746/full.md

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Source: https://tomesphere.com/paper/PMC12291746