# COR-KNOT-induced aortic root injury during minimally invasive aortic valve replacement of a bicuspid aortic valve: a case report

**Authors:** Takahiro Ishigaki, Kazuma Okamoto, Satoshi Asada, Genichi Sakaguchi

PMC · DOI: 10.1186/s44215-025-00217-2 · General Thoracic and Cardiovascular Surgery Cases · 2025-07-24

## TL;DR

A rare aortic root injury caused by the COR-KNOT device during a minimally invasive heart valve surgery is reported, emphasizing the need for careful device use in complex cases.

## Contribution

Reports a rare complication of aortic root injury associated with COR-KNOT device use during minimally invasive aortic valve replacement.

## Key findings

- A 72-year-old patient experienced aortic root injury from COR-KNOT clip sites during surgery.
- The injury required conversion to open surgery and repair with a pericardial patch.
- The case underscores the importance of careful device selection and clip placement in complex anatomies.

## Abstract

The COR-KNOT device is widely used in minimally invasive cardiac surgery, and its efficacy in reducing operative time is well established. However, it has been associated with complications, such as valve leaflet perforation and prosthetic valve damage.

We report a rare case of aortic root injury caused by COR-KNOT usage. A 72-year-old man with severe aortic stenosis due to a bicuspid aortic valve and distorted aortic root anatomy underwent minimally invasive aortic valve replacement using the COR-KNOT. After aortotomy closure, vigorous bleeding from the aortic root was observed. Punctate injuries of the aortic root, corresponding to the COR-KNOT clip sites, were identified following re-aortic cross-clamping. The procedure was converted to median sternotomy, the aortic root injury was repaired with an autologous pericardial patch, and the bioprosthetic valve was re-implanted using hand-tied sutures. The patient recovered uneventfully.

This case highlights the importance of careful device selection and clip positioning in anatomically challenging cases to avoid life-threatening complications.

## Linked entities

- **Diseases:** aortic stenosis (MONDO:0042981)

## Full-text entities

- **Diseases:** aortic stenosis (MESH:D001024), bicuspid aortic valve (MESH:D000082882), bleeding (MESH:D006470), aortic root (MESH:D000094628), Punctate injuries of (MESH:D014947)
- **Chemicals:** COR (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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Source: https://tomesphere.com/paper/PMC12291292