# Granulomatosis With Polyangiitis (GPA): A Case Report

## TL;DR

This case report describes a young woman diagnosed with GPA, a rare vasculitis disease, after experiencing persistent symptoms and abnormal imaging findings.

## Contribution

The novelty lies in presenting a rare clinical case of GPA in a young female with atypical initial symptoms.

## Key findings

- The patient had persistent dry cough, weight loss, and lung infiltrates that led to GPA diagnosis.
- Biopsy confirmed GPA vasculitis associated with ANCA-related inflammation.
- The case highlights the importance of considering GPA in patients with unexplained respiratory and systemic symptoms.

## Abstract

Granulomatosis with polyangiitis (GPA) is a rare necrotizing vasculitis disease affecting small to medium vessels. The exact cause of GPA is not fully understood, but the inflammation is associated with anti-neutrophil-cytoplasmic-antibody (ANCA). GPA involves the upper and lower respiratory tract, systemic vasculitis, and glomerulonephritis. This case report describes a young female patient presenting with a dry cough for a month that did not improve with Bactrim, weight loss, sinusitis, mastoid effusion, and multiple mass-like infiltrates in the lungs on imaging, who was found to have GPA vasculitis after being confirmed with a biopsy.