# Evaluation of 198Au Nanoparticles Coated with Gum Arabic for Prostate Cancer: A Contextual Comparison with BSA-Coated

## TL;DR

This study evaluates gum arabic-coated radioactive gold nanoparticles for prostate cancer treatment, showing they are stable, low-toxic, and effective in reducing tumor growth in animal models.

## Contribution

The study introduces a new gum arabic-coated 198AuNP formulation with a distinct synthesis method and evaluates its therapeutic potential for prostate cancer.

## Key findings

- GA-coated 198AuNPs showed good stability and low toxicity in non-tumor cells.
- The nanoparticles demonstrated tumor retention and reduced tumor growth in animal models.
- The GA formulation offers a feasible alternative to BSA-coated nanoparticles for prostate cancer treatment.

## Abstract

Prostate cancer, a leading cause of morbidity and mortality
among
men, requires safer and more effective therapeutic approaches. Nanotechnology
has emerged as a promising strategy to optimize therapeutic agent
distribution and reduce adverse effects of conventional treatments.
This study presents the development and evaluation of radioactive
gold nanoparticles (198AuNPs) coated with gum arabic (GA)
for prostate cancer treatment. While BSA-coated nanoparticles have
been previously studied by our group, demonstrating therapeutic effectiveness,
stability, and biocompatibility, the current work focuses exclusively
on the GA formulation, which features a distinct synthesis protocol. In vitro and in vivo assays with 198AuNPs-GA demonstrated good stability, low toxicity in nontumor cells,
tumor retention, and reduced tumor growth in animal models. References
to BSA are included only for contextual comparison. These findings
support the feasibility of gum arabic-coated 198AuNPs and
offer new insights for enhancing future clinical strategies.