# Intracoronary Optical Coherence Tomography: Technological Innovations and Clinical Implications in Cardiology

**Authors:** Yuchen Jiang, Jingyi Wang, Raksha Sreeramachandra Murthy, Pranav Patel, Zhongping Chen

PMC · DOI: 10.1007/s11936-025-01103-4 · Current Treatment Options in Cardiovascular Medicine · 2025-07-24

## TL;DR

Intracoronary OCT is a high-resolution imaging tool that improves diagnosis and treatment of coronary artery disease by providing detailed views of atherosclerotic lesions.

## Contribution

The paper highlights recent technological innovations in OCT and their clinical implications for advancing cardiology.

## Key findings

- OCT offers superior imaging resolution and functional classification of atherosclerotic lesions.
- OCT improves long-term clinical outcomes compared to traditional angiography.
- Combining OCT with multimodality imaging and AI can enhance diagnostic capabilities and risk stratification.

## Abstract

To provide the most up-to-date clinical evidence of intracoronary optical coherence tomography (OCT), and clinical implications to guide future imaging research in cardiology.

Intracoronary OCT has demonstrated advanced system performance and high reproducibility in analyzing atherosclerotic lesions. It is an attractive tool due to its capability for functional classification and superior imaging resolution, enabling precise and reliable tissue assessments. Compared to traditional angiography, OCT has been associated with improved long-term clinical outcomes and serves as an effective tool for optimizing stent selection and post-intervention evaluation. The development of OCT variations and the combination of various intravascular imaging modalities further enhance its diagnostic capabilities, allowing a comprehensive assessment of complex vulnerable lesions and improving risk stratification for patients.

Current and evolving system development presents a hopeful path for treating coronary artery disease by addressing the challenges of the intracoronary OCT technique. Future studies focusing on utilizing OCT system extensions, integrated multimodality imaging systems, and Artificial Intelligence (AI) derived image analysis will improve clinical endpoints and streamline the process.

## Linked entities

- **Diseases:** coronary artery disease (MONDO:0005010)

## Full-text entities

- **Diseases:** atherosclerotic lesions (MESH:D050197), coronary artery disease (MESH:D003324)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12289833/full.md

## References

2 references — full list in the complete paper: https://tomesphere.com/paper/PMC12289833/full.md

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Source: https://tomesphere.com/paper/PMC12289833