# Leber Hereditary Optic Neuropathy and Epilepsy in a Mexican Patient

## TL;DR

A Mexican woman in her 30s with Leber hereditary optic neuropathy also developed epilepsy, showing how mitochondrial disorders can affect multiple neurological systems.

## Contribution

This case report highlights the rare comorbidity of LHON and epilepsy, emphasizing the need for broader understanding of mitochondrial disease impacts.

## Key findings

- The patient had LHON and developed epilepsy in adolescence.
- MRI and EEG confirmed left temporal lobe epilepsy.
- Seizures ceased after adjusting anticonvulsant medication.

## Abstract

This case describes a woman in her 30s who was diagnosed with Leber hereditary optic neuropathy (LHON), a genetic disorder causing vision loss associated with mitochondrial DNA mutations. Initially diagnosed in childhood, she also developed epilepsy in adolescence. Despite treatment with multiple anticonvulsants, her initial seizures were only partially controlled. Brain MRI and scalp EEG results indicated left temporal lobe epilepsy, and she ceased seizures after modification of her anticonvulsant medication regimen. This rare comorbidity highlights the complexity of LHON, which often presents with additional neurological symptoms beyond vision loss. It underscores the need for comprehensive treatment and further research into mitochondrial diseases and their broader neurological impact.