Adenosquamous carcinoma of the gallbladder: case report of a rare entity

TL;DR

This paper reports a rare case of adenosquamous carcinoma of the gallbladder in a 56-year-old woman who underwent extensive surgery.

Contribution

The novelty lies in presenting a detailed clinical case of a rare gallbladder cancer subtype with aggressive behavior.

Findings

Adenosquamous carcinoma of the gallbladder is rare and more aggressive than adenocarcinoma.

Radical cholecystectomy with liver resection was performed for a moderately differentiated ASC case.

Complete surgical resection remains the primary treatment approach for this aggressive subtype.

Abstract

Adenocarcinoma constitutes 90%–95% of all malignant gallbladder (GB) neoplasms, making it the predominant subtype. In contrast, adenosquamous carcinoma (ASC) is significantly less common and comprises both glandular and squamous components. This subtype is more aggressive and has a worse prognosis than GB adenocarcinoma. Currently, complete surgical resection remains the cornerstone of treatment. In this paper, we present the case of a 56-year-old female diagnosed with moderately differentiated ASC of the GB, who underwent radical cholecystectomy, including the resection of liver segments IVb and V.

Figures