# Shield ulcer in keratoconus in the absence of atopic or vernal kerato-conjunctivitis

**Authors:** Magdalena Niestrata, Shuchi Kohli, Mohammad Saleki, Zahra Ashena

PMC · DOI: 10.3205/oc000253 · 2025-06-12

## TL;DR

A rare case of shield ulcer in a patient with keratoconus, without typical allergic conditions, is reported along with a new treatment approach using dry amniotic membrane.

## Contribution

Reports a unique case of shield ulcer in keratoconus without atopic or vernal keratoconjunctivitis and introduces a novel treatment technique.

## Key findings

- Shield ulcer occurred in a patient with keratoconus but no history of atopic or vernal keratoconjunctivitis.
- A new technique using dry amniotic membrane was successfully used to manage persistent epithelial defects in shield ulcers.

## Abstract

Corneal shield ulcer is a severe complication of atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC). This condition is caused by the mechanical irritation of the corneal epithelium due to giant papillae and toxic epitheliopathy resulting from inflammatory mediators. To date, there have been no reported cases of corneal shield ulcers in the literature without AKC or VKC. However, the authors have reported a unique case of shield ulcer in a patient with keratoconus but no history of AKC or VKC. The cause is hypothesised to be due to mechanical friction between the corneal steep apex and palpebral conjunctiva. Additionally, a new technique, the use of a dry amniotic membrane, is described to manage the persistent epithelial defect in shield ulcers.

## Linked entities

- **Diseases:** atopic keratoconjunctivitis (MONDO:0015599), vernal keratoconjunctivitis (MONDO:0019085), keratoconus (MONDO:0015486)

## Full-text entities

- **Diseases:** kerato-conjunctivitis (MESH:D003231), Corneal shield ulcer (MESH:D003320), Shield ulcer (MESH:D014456), AKC (MESH:D007637), epithelial (MESH:D009375), keratoconus (MESH:D007640), VKC (MESH:D003233), inflammatory (MESH:D007249)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

9 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12286868/full.md

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Source: https://tomesphere.com/paper/PMC12286868