# What are the clinical (endoscopic) differentials of celiac disease in dyspeptic syndrome?

## TL;DR

This study finds that 3% of patients with dyspeptic syndrome have celiac disease, highlighting its potential as a differential diagnosis.

## Contribution

The study provides a prevalence estimate of celiac disease in uninvestigated dyspepsia patients, aiding clinical decision-making.

## Key findings

- Celiac disease prevalence was 3% in patients with dyspeptic syndrome.
- Gluten-related symptoms were reported in 6% of patients.
- Antitissue transglutaminase IgA positivity was observed in 1.5% of patients.

## Abstract

Celiac disease is autoimmune disease associated with gluten that affects the small intestine Dyspeptic symptoms may be part of the clinical manifestations of celiac disease The prevalence of celiac disease in patients with a clinical diagnosis of dyspeptic syndrome was 3%

Celiac disease is autoimmune disease associated with gluten that affects the small intestine

Dyspeptic symptoms may be part of the clinical manifestations of celiac disease

The prevalence of celiac disease in patients with a clinical diagnosis of dyspeptic syndrome was 3%

Celiac disease is an autoimmune disease associated with gluten that affects the small intestine. Dyspeptic symptoms may be part of the clinical manifestations of celiac disease, but it is not clear whether patients with dyspepsia alone have a higher risk of celiac disease than individuals in the general population. Therefore, there are discrepancies in relation to the prevalence of celiac disease in dyspeptic syndrome, and hence further epidemiological studies are necessary in order to establish in the future in whom celiac disease research should be performed.

The prevalence of celiac disease in patients with a clinical diagnosis of dyspeptic syndrome was 3%, and the sample was characterized by an average age of 45.13 years; predominance of females; and glutenrelated symptoms in 6%; endoscopic signs of celiac disease in 2.5%; serological positivity of 1.5%; and histological signs of celiac disease in 3% of the biopsied patients.

Dyspepsia is a set of symptoms of the upper abdomen and has a prevalence of 10–45% of the population with different etiological possibilities, including celiac disease.

The aim of this study was to evaluate the prevalence of celiac disease in patients with a clinical diagnosis of dyspeptic syndrome.

This is an observational research, based on a review of medical records of patients treated for uninvestigated dyspepsia. Patients over 18 years of age, with uninvestigated dyspepsia, and who had upper endoscopy, total immunoglobulin A (IgA), and antitissue transglutaminase IgA were included. Those with diarrhea, constipation, malabsorption, refractory lactose intolerance, or who presented extraintestinal signs or symptoms suggestive of celiac disease were excluded.

The initial sample was 1,802 records and the final 200 patients. Considering the total sample, the average age was 45.13 years and the female sex was predominant. Symptoms associated with gluten were reported in 6% of the patients. The antitissue transglutaminase IgA was positive in 1.5% of the patients. Considering the sample of 100 patients, the diagnosis of celiac disease had a prevalence of 3%.

The prevalence of celiac disease in patients with a clinical diagnosis of dyspeptic syndrome was 3%.