Acetylenic Metabolites and a 2-Phenoxychromone Derivative from the Aerial Parts of Artemisia biennis

TL;DR

This study isolated two acetylenic metabolites and a 2-phenoxychromone derivative from Artemisia biennis, which showed cytotoxic and antifungal properties.

Contribution

The isolation and characterization of two acetylenic metabolites and a 2-phenoxychromone derivative from A. biennis is novel.

Findings

Two acetylenic metabolites and a 2-phenoxychromone derivative were isolated from the DCM extract of A. biennis.

The compounds showed biological effects consistent with the previously reported cytotoxic and antifungal activities of the extract.

The isolated compounds have chemotaxonomic significance.

Abstract

Artemisia biennis is a weed of several crops, but some valuable biological effects have been reported from its various extracts.

The present phytochemical study was carried out on the dichloromethane (DCM) extract of the aerial parts of A. biennis. The prominent cytotoxic and antifungal activities of this extract were previously reported.

The DCM extract was fractionated using vacuum-liquid chromatography (VLC). The selected fractions were purified by VLC and semi-preparative high-performance liquid chromatography (HPLC). The structures of the isolated compounds were characterized by comprehensive spectroscopic analyses.

Two acetylenic metabolites [(E)-en-yn-dicycloether, (Z)-en-yn-dicycloether], and a 2-phenoxychromone derivative (6-demethoxy-4'-O-methylcapillarisin) were isolated from the DCM extract of A. biennis aerial parts.

These two acetylenic metabolites have exhibited various effects on biological systems. The results of this study are in accordance with the reported cytotoxic and antifungal activities of the DCM extract of A. biennis. The chemotaxonomic significance of the isolated compounds is also notable.

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