# Anesthesia Management Involving Remimazolam in a Patient With Pulmonary Hypertension and Right Ventricular Failure: A Case Report

**Authors:** Masato Ryo, Yusuke Ishida, Masahiro Hamaguchi, Maiko Hosokawa, Katsunori Oe

PMC · DOI: 10.7759/cureus.86568 · 2025-06-22

## TL;DR

This case report shows that remimazolam can safely manage anesthesia in a patient with pulmonary hypertension and right ventricular failure.

## Contribution

The novel contribution is demonstrating the safe use of remimazolam in a high-risk patient with pulmonary hypertension and right ventricular failure.

## Key findings

- Anesthesia with remimazolam maintained hemodynamic stability in a patient with pulmonary hypertension.
- Transesophageal echocardiography showed no worsening of pulmonary hypertension or right ventricular failure during the procedure.
- The patient had an uneventful postoperative recovery and was discharged without complications.

## Abstract

In the anesthetic management of patients with pulmonary hypertension (PH), it is essential to minimize right ventricular (RV) load and prevent abrupt changes in pulmonary vascular resistance (PVR). We report a case in which safe anesthetic management was achieved without circulatory collapse by using remimazolam in a patient with PH. An 84-year-old woman was scheduled to undergo percutaneous left atrial appendage closure for non-valvular atrial fibrillation. She had developed secondary PH and RV failure secondary to atrial fibrillation and systemic sclerosis, necessitating careful general anesthesia with positive pressure ventilation. Total intravenous anesthesia was administered using remifentanil and remimazolam. Hemodynamic stability was maintained throughout induction and intraoperative management. Transesophageal echocardiography performed during the procedure revealed no exacerbation of PH or RV failure, and the percutaneous catheter procedure was completed uneventfully. The patient’s postoperative course was also uneventful, and she was discharged without any serious complications. Anesthesia management using remimazolam might be beneficial in patients with PH, as it provides stable hemodynamics and allows for safe perioperative care.

## Linked entities

- **Chemicals:** remimazolam (PubChem CID 9867812), remifentanil (PubChem CID 60815)
- **Diseases:** pulmonary hypertension (MONDO:0005149), atrial fibrillation (MONDO:0004981), systemic sclerosis (MONDO:0005100)

## Full-text entities

- **Diseases:** circulatory collapse (MESH:D012769), RV failure (MESH:D051437), PH (MESH:D006976), atrial fibrillation (MESH:D001281), systemic sclerosis (MESH:D012595)
- **Chemicals:** remifentanil (MESH:D000077208), Remimazolam (MESH:C522201)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12284381/full.md

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Source: https://tomesphere.com/paper/PMC12284381