Non-invasive bio-electromagnetic monitoring of cerebrovascular function: a novel conductivity reactivity index (CRx) for optimal cerebral perfusion pressure in acute brain injury models

TL;DR

This study introduces a non-invasive method using bio-electromagnetic monitoring to assess cerebrovascular function in acute brain injury models.

Contribution

A novel non-invasive conductivity reactivity index (CRx) is proposed to evaluate optimal cerebral perfusion pressure.

Findings

CRx showed a significant negative correlation with the pressure reactivity index (PRx) in acute brain injury models.

Under optimal cerebral perfusion pressure, CRx indicated normal cerebrovascular function, differing significantly from other states.

The study highlights the potential of bio-electromagnetic technology for non-invasive cerebrovascular monitoring.

Abstract

The pressure reactivity index (PRx) is a key predictor of cerebrovascular function, widely used to guide and optimize therapeutic strategies in patients with acute brain injury. This study investigates a non-invasive bio-electromagnetic technique for monitoring and maintaining cerebrovascular function in a rabbit model of acute brain injury.

A coaxial parallel double-coil sensor was designed to detect changes in intracranial electromagnetic properties, measured as magnetic induction phase shifts (MIPS), which reflect cerebral blood volume fluctuations. A cerebrovascular function monitoring platform was constructed with this sensor, a vector network analyzer, a LabVIEW software platform, and a physiological signal acquisition device to record the MIPS and arterial blood pressure (ABP). In the animal experiment, a novel cerebrovascular function index Conductivity Reactivity index (CRx), established with MIPS and ABP, was to assess optimal cerebral blood perfusion pressure (CPP) for maintaining the cerebrovascular function in four gradients of CPP in acute brain injury model.

The results found that the CRx (−0.072 ± 0.203) was a significant negative correlation with the PRx (0.223 ± 0.203) (r = −0.447, P = 0.003). Under the optimal CPP determined by the CPP-CRx curve, the mean CRx (0.104 ± 0.170) indicated normal cerebrovascular function, which was significantly different from the other states (CRx = −0.127 ± 0.061, p = 0.009).

The study demonstrated that CRx has potential to reflect cerebrovascular function dynamics and assess optimal CPP, demonstrating the potential of bio-electromagnetic technology as a noninvasive indicator for monitoring cerebrovascular function.

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