# Case Report: Ultrasound-guided microwave ablation combined with postoperative radiotherapy and chemotherapy for advanced tongue cancer

**Authors:** Ting Wei, Jiulong Dai, Tingting Li, Ziyue Hu, Lu Wang, Juan Li, Jie Zou, Jia Feng, Man Lu

PMC · DOI: 10.3389/fonc.2025.1564348 · 2025-07-09

## TL;DR

This case report shows that a minimally invasive treatment combining microwave ablation with radiotherapy and chemotherapy can effectively treat advanced tongue cancer while preserving function.

## Contribution

The paper presents a novel clinical case using ultrasound-guided microwave ablation as an alternative to surgery for advanced tongue cancer.

## Key findings

- Ultrasound-guided microwave ablation at 30 W power showed no enhancement in the ablation area post-procedure.
- The patient had no complications and retained normal speech and swallowing after over two years of follow-up.
- Combining MWA with radiotherapy and chemotherapy resulted in no recurrence or metastasis.

## Abstract

While surgery remains the standard treatment for tongue cancer, it is associated with a range of functional and aesthetic sequelae. Additionally, ultrasound-guided microwave ablation (MWA) represents a promising minimally invasive alternative for patients with poor performance status or those unwilling to undergo surgery.

We report a 50-year-old male patient diagnosed with advanced tongue squamous cell carcinoma and cervical lymph node metastases. Microwave ablation was performed using a power setting of 30 W. Contrast-enhanced ultrasound conducted immediately afterward revealed no enhancement in the ablation area. Following the ablation, the patient received adjuvant radiotherapy and chemotherapy. During the procedure, the patient experienced minimal pain and no significant complications. After more than two years of follow-up, no evidence of metastasis or recurrence was observed, and the patient retained normal speech and swallowing functions.

Ultrasound-guided MWA combined with radiotherapy and chemotherapy offers a safe, effective, and minimally invasive approach to the treatment of advanced tongue cancer.

## Linked entities

- **Diseases:** tongue cancer (MONDO:0004631), tongue squamous cell carcinoma (MONDO:0000500)

## Full-text entities

- **Diseases:** metastasis (MESH:D009362), tongue cancer (MESH:D014062), cervical lymph node metastases (MESH:D008207), tongue squamous cell carcinoma (MESH:D000077195), pain (MESH:D010146)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12283613/full.md

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Source: https://tomesphere.com/paper/PMC12283613