# Importance of Targeted Communication Strategies During COVID-19 Vaccination Campaigns in Mozambique: Results of a Mixed-Methods Acceptability Study

**Authors:** Caroline De Schacht, Igor Ubisse Capitine, Carlota Lucas, Ana Muteerwa, Paula Paulo, Alvaro Manhiça, Fernando Padama, Celso Belo, Leonildo Nhampossa, Graça Matsinhe, Zhihong Yu, C William Wester

PMC · DOI: 10.1093/cid/ciaf054 · Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America · 2025-07-22

## TL;DR

A study in Mozambique found that targeted communication strategies can improve vaccine acceptance by addressing myths and misinformation during the COVID-19 vaccination campaign.

## Contribution

The study introduces the effectiveness of mixed-methods approaches in identifying barriers and motivators for vaccine acceptance in diverse populations.

## Key findings

- Most participants learned about vaccines through radio and television.
- Myths, misinformation, and long queues were key barriers to vaccination.
- Targeted campaigns involving health professionals and community leaders can increase vaccine uptake.

## Abstract

Mozambique implemented a phased roll-out of COVID-19 vaccination in 2021. This study aimed to evaluate COVID-19 vaccine acceptability among higher-risk populations in Zambézia Province.

A mixed-methods study in Zambézia Province assessed knowledge, perceptions, and acceptability of COVID-19 vaccination. Structured questionnaire-based surveys among community health workers/volunteers, taxi drivers, and persons with HIV; and focus group discussions using semi-structured guides with community/religious leaders, adults aged 18–49 years and adults aged 50+ years were conducted in August–September 2021. Surveys were captured using tablets; group discussions were recorded. Univariate analyses were performed for quantitative data; qualitative data were analyzed thematically.

A total of 731 individuals participated (539 survey respondents; 192 discussion respondents); 53% male (n = 386) and 74% urban (n = 544) residents. Most had heard about COVID-19 vaccines, mainly through television and/or radio. Trustworthy information sources mentioned were community leaders and healthcare providers. Among survey respondents, 249/539 (46%) reported having received at least 1 vaccine dose. Motivators for vaccination mentioned by survey respondents were “belief that vaccines protect themselves” (72%), “belief it would protect their family” (17%). Myths and beliefs, misinformation, and long queues were main barriers for vaccination mentioned in group discussions. Participants suggested that campaigns should focus on communication talks led by health professionals, in partnership with community or church leaders and/or community health workers/volunteers.

This study showed that information on COVID-19 vaccination had successfully reached the vast majority of study participants, mainly via radio and television. Targeted campaigns specific for rural and urban contexts can increase awareness and uptake of vaccination.

This mixed-methods study conducted in Mozambique showed that information regarding COVID-19 vaccination reached the population. About half accepted vaccination, where myths, misinformation, wait time were seen as barriers. Targeted campaigns adapted for different contexts can increase awareness and vaccination uptake.

## Linked entities

- **Diseases:** COVID-19 (MONDO:0100096)

## Full-text entities

- **Diseases:** COVID-19 (MESH:D000086382)
- **Species:** Homo sapiens (human, species) [taxon 9606], Human immunodeficiency virus 1 (no rank) [taxon 11676]

## Full text

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## Figures

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## References

42 references — full list in the complete paper: https://tomesphere.com/paper/PMC12282518/full.md

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Source: https://tomesphere.com/paper/PMC12282518