# Sweet Syndrome and Valley Fever: A Case Report

## TL;DR

A case report shows how Sweet’s syndrome can signal Valley fever, enabling early treatment before diagnostic results are available.

## Contribution

Highlights the diagnostic value of Sweet’s syndrome in identifying Valley fever in the emergency department.

## Key findings

- Painful bullous lesions were recognized as Sweet’s syndrome, suggesting Valley fever.
- Early treatment with fluconazole and prednisone improved symptoms before confirmatory tests.
- Clinical recognition of cutaneous findings led to timely therapeutic intervention.

## Abstract

Sweet’s syndrome, also referred to as erythema sweetobullosum, is a rare dermatologic condition that may serve as a clinical diagnostic clue in the emergency department (ED) for coccidioidomycosis, commonly known as Valley fever. This case describes a patient who presented with the acute onset of painful bullous lesions on the forearms, chest, and anterior legs. Recognition of these cutaneous findings as Sweet’s syndrome, in conjunction with a high index of suspicion for Valley fever, led to the initiation of appropriate treatment with fluconazole and prednisone prior to the return of confirmatory coccidioidomycosis serologies. Early therapeutic intervention resulted in symptomatic improvement.